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iderrinri - Imaging Pet Reporter Transgenes in Living Subjects pdf
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Imaging Pet Reporter Transgenes in Living Subjects pdf

یکشنبه 28 تیر 1394

نویسنده: Philip Andrews |

Imaging Pet Reporter Transgenes in Living Subjects by Shahriar Yaghoubi
Imaging Pet Reporter Transgenes in Living Subjects
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Author: Shahriar Yaghoubi
Page Count: 216 pages
Published Date: 18 Feb 2009
Publisher: VDM Verlag
Publication Country: Germany
Language: English
ISBN: 9783639115178
File Name: Imaging.Pet.Reporter.Transgenes.in.Living.Subjects.pdf
Download Link: Imaging Pet Reporter Transgenes in Living Subjects
---------------------------------------------------------------


Non-invasive imaging of transgene expression should soon play a critical role in gene and adoptive cellular gene therapy clinical trials. Positron emission tomography (PET) reporter genes (PRG)/probes (PRP) are currently the most advanced technologies available for imaging transgens in humans. PRGs can be used to image the location, magnitude, and time variation of the intensity of transgene expression throughout the whole body of a patient. This can eliminate the need for multiple biopsies, which are potentially dangerous and yet do not provide a complete picture of whole body transgene expression at multiple time points. This dissertation provides details of several studies on direct and indirect imaging of therapeutic transgenes using multiple PRG/PRP systems in mice. Furthermore, it includes the details of the first study on the pharmacokinetics, dosimetry, and safety of an imaging reporter probe in humans. Finally, a complete background on alternate methods of imaging transgene expression has been provided, concluding with a discussion of potential future applications of imaging in gene therapy.

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